Electroextraction

In March 2009, PharmaTec Magazine highlighted the importance of Electroextraction as a vehicle for efficient Downstream Bioprocessing of biopharmaceutical proteins. Under the title “How to Efficiently Recover Proteins from a Fermentation Broth” the article describes the technological advantages of utilizing a selective release and immediate capture of a targeted bioproduct.

Professor Fernández Lahore, Electroextraction Coordinator, explained that the novel technology would bring a solution for those companies facing difficulties during the recovery of intracellular (recombinant) products in yeast. The modern Life Science industry depends on efficient bioprocess technologies, which should be able to generate competitive products or services in terms of quality and cost.

Impressive progress has been made in the capability of engineered cells to synthesize bioproducts in culture. However, the recovery and purification of such biomolecules (also referred as downstream processing) still poses a number of important challenges. This pushes-up the cost and price of (bio) drugs, slows down their development and limits their accessibility to the community of patients. The industrial community recognizes that nowadays a major obstacle to becoming competitive is the elevated costs associated with product downstream processing.

Partners

Downstream Bioprocessing Laboratory, School of Engineering and Science, Jacobs University, Campus Ring 1, 28759, Bremen, Germany
Principal Investigators
Prof. Dr. M. Fernandez-Lahore
Dr. Rami Reddy Vennapusa

Department of Biophysics and Radiobiology, Sofia University, 8 blvd Dragan Tzankov, 1164 Sofia, Bulgaria
Principal Investigators
Prof. Valentina Ganeva
Prof. Bojidar Galutzov

Institut de Pharmacologie et de Biologie Structurale / CNRS, UMR 5089-CNRS, 205 Route de Narbonne, 31077 Toulouse, France
Principal Investigator
Prof. Justin Teissie

Biomedal S.L.,
Avda. Américo Vespucio 5E. 1◦ M12,
41092 Seville, Spain
Principal Investigators
Dr. Miguel Arévalo-Rodríguez
Dr. Isabel Velasco