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Graduate Profile: Biochemical Engineering - Vetja Haakuria

2011-04-06T12:30:00.007+05:30

Lecture - 5 Specificity of Enzyme Action

2011-04-06T12:30:00.005+05:30

Lecture - 4 Enzymatic Catalysis

2011-04-06T12:30:00.004+05:30

Lecture - 3 Enzymes as Biocatalysts

2011-04-06T12:30:00.003+05:30

Lecture - 2 Characteristic Features of Enzymes

2011-04-06T12:30:00.002+05:30

Lecture - 1 Introduction and Scope to Enzyme Science & Engineering

2011-04-06T12:30:00.001+05:30

Bachelor of Engineering in Chemical & Biochemical Engineering at the University of Limerick LM115

2011-04-06T12:30:00.000+05:30

Watch Video at: http://www.youtube.com/watch?v=vsP95aeLqLU

Course Information: http://www.ul.ie/courses/LM115.html

7th Bio Production at Ulm, Germany

2011-03-13T11:25:00.000+05:30

The Bio Production, takes Place from 08 to 10 June 2011 in Ulm (near Stuttgart), Germany.

During the past 6 years, the European Compliance Academy’s (ECA) Bio Production Forum has become an international event bridging the world of academic research and development and the world of manufacturing biopharmaceuticals with a focus on proteins and monoclonal antibodies. The event has been supported by Ludwig Maximilians University Munich, Swiss Federal Institute of Technology Zürich, Leiden University and the Swiss Society of Pharmaceutical Sciences as well as the industrial partners Cilag AG, Merck Serono and Boehringer Ingelheim.

To strengthen the relationship between sciences and industry, the ECA initiated a poster session for this year’s Forum. For this poster session throughout the three conference days we would like to invite young scientists to present their work and would therefore appreciate it if you encouraged your students to submit posters.

For the first 10 registered young scientists, Boehringer and Cilag grant a participation free of charge. For posters submitted later, the ECA offers a reduced conference fee of 450.- €. This fee includes the participation in the conference, the social event and the site visit at Boehringer Ingelheim. Further, the ECA will award the three best posters with 300.-, 200,- and 100.- €.

Detailed information about the poster session and the conference can be found in the attachment or at www.bio-conference.org

Biochemical Engineer

2011-03-10T22:58:00.000+05:30

Biochemical engineering is a branch of chemical engineering that is geared towards applying engineering skills to conceive, design and develop processes and systems with the aim of creating new products. Due to the similarities involved in the material and curriculum subjects, and considering that both require similar problem solving skills applied in chemical and biological engineering, biochemical engineering is taught as a supplementary option. However, there are some colleges that offer biochemical engineering on its own.

How to become an biochemical engineer

You can become a biochemical engineer by studying towards earning grades that grant you an opening in this line, and most outstanding should be your performance in Mathematics and Chemistry as they are prerequisites when it comes to this course. This is where you ought to really stand out while in high school to have higher chances of qualifying for a course in a subject related to this career.

Types, Description, and Information

You must make sure that you are always sharpening your skills to best update yourself with the new technologies that are being developed daily due to the innovation coming from all quotas.

To work in this field, you need to have exceptional problem solving skills and be very analytical and innovative in thinking. You also must possess great people skills, since you are required to work in teams for the most part.

Qualifications: Courses, Training, Certification

You must possess at the very least a bachelor’s degree or higher in order to gain employment as a bio chemical engineer. You must also be registered as a professional engineer.

Schools, Colleges, Universities

Listed here are some of the top 5 colleges that offer programs related to bio chemical engineering

1. Stanford University, Palo CA

2. San Jose state University, San Jose C.A

3. Western Kentucky University, Bowling Green KY

4. Boise state University, Boise Idaho

5. Wichita State University, St. Wichita Kansas

Job Opportunities, Salaries and Recruitment

Biochemical engineers can work in many fields, just as long as there is a biological or chemical process conversion involved, trust to find them there, for example, in waste management, textile manufacturers, construction companies, to name but a few. They work alongside Scientists, Mathematicians, technicians and administrators and mainly work in chemical process industries that include food and beverage, chemical, gasoline and oils etc

Biochemical engineer’s salaries vary depending on the company they are working for or plan to work for, the average salary however is 72,490 dollars with the lowest earning 48,450 and the highest according to statistics earning 107,520 dollars annually.

Biochemical Engineer

2011-03-09T22:01:00.000+05:30

Description:

It would be hard to imagine a world without gasoline, paper, pharmaceuticals, fertilizers, plastics, synthetic fibers, paint, film or any other biochemical products we use and demand in our daily lives. Whether it is bettering already existing products or creating new ones, we generally take these engineering inventions for granted because we have grown up with many of them and for that very reason, they seem like they have always been around. Yet the work and discoveries made by biochemical engineers have had an overwhelming impact on all of our lives.

Applying scientific and mathematical principles, biochemical engineers develop processes, design equipment, and provide technical and management services for plants and manufacturing companies that convert raw materials into a wide range of end products, like pharmaceuticals, food and fuels. They are concerned with the large-scale culture of living cells in fermentation processes.

Biochemical engineers are constantly putting their creativity to work, synthesizing new materials, transforming combinations of elements of matter and developing the processes to do it all safely, efficiently and on a large scale. Different areas of biological engineering include biotechnology, biomedical studies, food processing, agriculture and environmental studies. Biochemical engineers process and package many of the foods we eat, develop new medicines, help power our cars and heat our homes. For example, a biochemical engineer could work for a food manufacturer, making sure that the food processed is safe for human consumption (no e-coli or salmonella) or one could work in the health industry, making sure that medical waste is properly disposed of.

Biochemical engineers are like alchemists; they turn living or raw materials into valuable products. They usually work with a team of biologists and chemists because while scientists develop the products, the engineers create the processes required to produce them commercially.

Biochemical engineers extract existing data and design methods to design equipment and operating specifications for industrial plants. They take into account cost, safety and environmental concerns when conducting research and performing experiments. Biochemical engineers working in plants must ensure that the equipment is operating efficiently and safely and that the desired quantity and quality of product is produced. They often meet with manufacturers, lawyers and clients to make sure that design plans are safe and will withstand a number of conditional variables.

Biochemical engineers are required to constantly update their skills and knowledge in order to keep up with technological advancements in this quickly changing field.

How to Make and Run an Agarose Gel (DNA Electrophoresis)

2011-02-12T00:02:00.001+05:30

How to Use a Centrifuge

2011-02-12T00:01:00.000+05:30

Single Cell Gene Expression Analysis Workflow

2011-01-31T23:25:00.001+05:30

Confocal Microscope Training

2011-01-31T23:23:00.001+05:30

FRET - Fluorescence Resonance Energy Transfer - Dr Othon Gervasio - 3D Scientific Animation

2011-01-31T23:21:00.001+05:30

Agilent RNA kit Better RNA purity, less work, longer lunch

2011-01-31T23:20:00.001+05:30

Nanodrop it like it's hot! Nanodrop

2011-01-31T23:18:00.001+05:30

Agilent 2100 Bioanalyzer - Work it into your routine

2011-01-31T23:16:00.001+05:30

Roche LightCyler 480

2011-01-31T23:15:00.001+05:30

Agilent's Stratagene Real-Time PCR (qPCR) System

2011-01-31T23:14:00.001+05:30

PCR - DNA Fingerprinting

2011-01-31T23:12:00.001+05:30

Intro to Polymerase Chain Reaction (PCR)

2011-01-31T23:10:00.001+05:30

Real-Time Polymerase Chain Reaction (PCR)

2011-01-31T23:09:00.001+05:30

Real Time QPCR Data Analysis Tutorial (part 2)

2011-01-31T23:07:00.001+05:30

Real Time QPCR Data Analysis Tutorial

2011-01-31T23:06:00.001+05:30

Key Steps for Generating Real-Time PCR Data that Conforms to MIQE Guidelines, Part 4 of 4

2011-01-31T23:04:00.001+05:30

Key Steps for Generating Real-Time PCR Data that Conforms to MIQE Guidelines, Part 3 of 4

2011-01-31T23:03:00.001+05:30

Key Steps for Generating Real-Time PCR Data the Conforms to MIQE Guidelines, Part 2 of 4

2011-01-31T23:02:00.001+05:30

Key Steps for Generating Real-Time PCR Data that Conforms to MIQE Guidelines, Part 1 of 4

2011-01-31T23:01:00.000+05:30

Automated systems for real-time PCR analysis

2011-01-31T23:00:00.000+05:30

Automated setup of SYBR green realtime PCR

2011-01-31T22:59:00.000+05:30

How SYBR Works

2011-01-31T22:58:00.000+05:30

Real-time PCR

2011-01-31T22:57:00.000+05:30

RNA Extraction from Cell Culture

2011-01-31T22:56:00.000+05:30

RNA Isolation

2011-01-31T22:54:00.001+05:30

2D PAGE

2011-01-31T22:53:00.001+05:30

IEF Electrophoresis Part 2

2011-01-31T22:51:00.001+05:30

IEF Electrophoresis Part 1

2011-01-31T22:50:00.001+05:30

ISOELECTRIC FOCUSING

2011-01-31T22:49:00.000+05:30

Introduction to 2D Gel Electrophoresis

2011-01-31T22:47:00.002+05:30

How to run a gel electrophoresis

2011-01-31T22:47:00.000+05:30

Basic idea behind gel electrophoresis

2011-01-31T22:45:00.001+05:30

How to Make and Run an Agarose Gel (DNA Electrophoresis)

2011-01-31T22:44:00.001+05:30

Calibration of a pH Meter

2011-01-31T22:43:00.001+05:30

Lab Equipment: pH measurement with paper and meters [Part 2]

2011-01-31T22:42:00.000+05:30

Lab Equipment: pH measurement with paper and meters [Part 1]

2011-01-31T22:41:00.001+05:30

Volumetric Techniques | MIT Digital Lab Techniques Manual

2011-01-31T22:40:00.000+05:30

Column Chromatography | MIT Digital Lab Techniques Manual

2011-01-31T22:38:00.000+05:30

Buffers and pH Meter | MIT Digital Lab Techniques Manual

2011-01-31T22:37:00.000+05:30

How to Make pH Buffers

2011-01-31T22:35:00.001+05:30

How to Use a Pipette

2011-01-31T22:34:00.000+05:30

Pipette Demonstration

2011-01-31T22:33:00.000+05:30

Using A Pipette

2011-01-31T22:31:00.000+05:30

Pipetting Technique

2011-01-31T22:30:00.000+05:30

Serial Dilution

2011-01-31T22:28:00.001+05:30

Microbiology Dilution series demonstration

2011-01-31T22:27:00.001+05:30

Lecture 18 Introduction to Microbiology

2011-01-31T22:26:00.001+05:30

Introduction to Microbiology Culture Techniques

2011-01-31T22:25:00.001+05:30

The Work of a Clinical Biochemistry Laboratory (Part 2 of 2)

2011-01-31T22:24:00.000+05:30

The Work of a Clinical Biochemistry Laboratory (Part 1 of 2)

2011-01-31T22:23:00.000+05:30

Molecular Laboratory - BioChemistry

2011-01-31T22:21:00.000+05:30

1 h in the biochemistry lab compressed to 10 min

2011-01-31T22:19:00.001+05:30

Autoclave use in Molecular Biology Lab

2011-01-31T22:17:00.001+05:30

Candida tropicalis fermentation using advanced fed-batch algorithm

2011-01-31T22:14:00.000+05:30

Sacharomyces cerevisiae fed-batch fermentations using bioreactors EDF-5.3.1

2011-01-31T22:11:00.001+05:30

Starting up the Bioreactor

2011-01-31T22:10:00.000+05:30

ESC Bioreactor Test #2

2011-01-31T22:08:00.000+05:30

Embryonic Stem Cell Bioreactor Test #1

2011-01-31T22:04:00.001+05:30

Algae Bioreactor at night

2011-01-31T22:03:00.001+05:30

Bioreactor

2011-01-31T22:02:00.000+05:30

Bioreactor

2011-01-31T21:59:00.000+05:30

Origins of Biotechnology and Bioengineering: Part 2

2011-01-31T21:56:00.001+05:30

Origins of Biotechnology and Bioengineering: Part 1

2011-01-31T21:54:00.000+05:30

Electroextraction

2011-01-31T19:40:00.000+05:30

In March 2009, PharmaTec Magazine highlighted the importance of Electroextraction as a vehicle for efficient Downstream Bioprocessing of biopharmaceutical proteins. Under the title “How to Efficiently Recover Proteins from a Fermentation Broth” the article describes the technological advantages of utilizing a selective release and immediate capture of a targeted bioproduct.

Professor Fernández Lahore, Electroextraction Coordinator, explained that the novel technology would bring a solution for those companies facing difficulties during the recovery of intracellular (recombinant) products in yeast. The modern Life Science industry depends on efficient bioprocess technologies, which should be able to generate competitive products or services in terms of quality and cost.

Impressive progress has been made in the capability of engineered cells to synthesize bioproducts in culture. However, the recovery and purification of such biomolecules (also referred as downstream processing) still poses a number of important challenges. This pushes-up the cost and price of (bio) drugs, slows down their development and limits their accessibility to the community of patients. The industrial community recognizes that nowadays a major obstacle to becoming competitive is the elevated costs associated with product downstream processing.

Partners

Downstream Bioprocessing Laboratory, School of Engineering and Science, Jacobs University, Campus Ring 1, 28759, Bremen, Germany
Principal Investigators
Prof. Dr. M. Fernandez-Lahore
Dr. Rami Reddy Vennapusa

Department of Biophysics and Radiobiology, Sofia University, 8 blvd Dragan Tzankov, 1164 Sofia, Bulgaria
Principal Investigators
Prof. Valentina Ganeva
Prof. Bojidar Galutzov

Institut de Pharmacologie et de Biologie Structurale / CNRS, UMR 5089-CNRS, 205 Route de Narbonne, 31077 Toulouse, France
Principal Investigator
Prof. Justin Teissie

Biomedal S.L.,
Avda. Américo Vespucio 5E. 1◦ M12,
41092 Seville, Spain
Principal Investigators
Dr. Miguel Arévalo-Rodríguez
Dr. Isabel Velasco

BETAtech,
15 rue d’Apollo, Z.A. de Montredon,
31240 l’Union, France
Principal Investigators
Mr. Eric Danoy
Mr. Mr. Régis Ficat

ROMB, 1, Aboba Str., box 5
1606 Sofia, Bulgaria
Principal Investigators
Dr. Valentin Savov
Ms. Anna Kuyumdjieva
Ms. Tsvetana Licheva

Organo Balance,
Gustav-Meyer-Allee 25
13355 Berlin, Germany
Principal Investigators
Dr. Christine Lang
Dr. Detlef Goelling

For Further Information: Visit Electroextraction Website

PGZyme

2011-01-31T19:30:00.000+05:30

PGZyme combines a team of researchers performing basic and pre-industrial research on the production of pectinolytic enzymes by a GRAS certified, non-GMO microorganism, Aspergillus sojae, which holds great potential for pectinase production.

In order to obtain high yields of pectinase production, strain improvement and optimization of culture conditions is performed. The downstream process of technical and food enzymes represents a current technological bottleneck.

A suitable strategy will be developed to preserve the benefits obtained with the biosynthetic steps. Downstream processing will be designed and implemented in a cost-effective manner via novel fibrous adsorbents. The project is expected to deliver a pre-competitive technology which is based on a fungal platform employing A. sojae as a bio-factory.

Partners

Companies

ANTIBIÓTICOS S.A.
Member of the General Assembly: Dr. José Luis Barredo Fuente
Position: R&D Biology Manager
Tel. +34 (0)987-895826
Fax +34 (0)987-895986
León, Spain

BIOREACT GmbH
Member of the General Assembly: Dr. Jürgen Lenz
Position: General Manager
Tel. +49 (0)2241-854504
Fax +49 (0)2241-854503
Troisdorf, Germany

GUSERBIOT S.L.U.
Member of the General Assembly: Dr. Francisca Barbero Mangas
Position: Technical Manager
Tel. +34 (0)945-292700
Fax +34 (0)945-292919
Victoria, Spain

Research Institutions

IZMIR INSTITUTE OF TECHNOLOGY
Member of the General Assembly: Prof. Dr. Canan Balci Tari
Position: Professor of Food Engineering
Tel. +90 (0)232-7506316
Fax +90 (0)232-7506196
Urla, Izmir, Turkey

JACOBS UNIVERSITY BREMEN gGmbH
Member of the General Assembly: Prof. Dr. Marcelo Fernández-Lahore
Position: Professor of Biochemical Engineering
Tel. +49 (0)421-2003229
Fax +49 (0)421-2003660
Bremen, Germany

For further information: Visit PGZyme Website

China Bio Exchange

2011-01-31T19:17:00.000+05:30

This international collaboration was inspired by Dr. Fernandez-Lahore and Dr. Dong-Qiang Lin's enthusiasm for downstream bioprocessing and the impressive advantages it brings to a number of food-processing industries.

The prestigious Robert Bosch Foundation awarded the two prominent academics a research grant in 2009. This funding has enabled Dr. Fernandez-Lahore, Dr. Don-Qian Lin and their groups to focus on the development of cost-efficient ways to implement downstream bioprocessing in mainstream biological manufacturing.

Partners

Prof. Dr. Marcelo Fernández Lahore is the Director of the Downstream Bioprocessing Laboratory at Jacobs University Bremen, Germany. He and his research group work on the chromatographic characterization of novel materials for chromatography.

These investigations also include detailed study of the separation behaviour of (bio) products and contaminants during processing. Dr. Fernández Lahore’s group has implemented a routine based on modern proteomic tools. In essence, a complex biological sample is subjected to chromatography under standard conditions, fractions are collected, and further analysed by two-dimentional gel electrophoresis and mass spectrometry.

As a result, general tendencies are observed within the population of the separand entities and contaminants are identified. In the particular case of mixed-mode ligands, interaction effects with soluble proteins are complex and thus, “process-proteomics” is able to generate a much better understanding and predictability of the processes involved.

Prof. Dr. Dong-Qiang Lin’s lab at Zhejiang University in China has developed multi-functional ligands for mixed-mode chromatography. Mixed-mode chromatography is a new kind of chromatographic technology for bioseparation.

Mixed-mode ligands have multiform binding functions, commonly combining hydrophobic and electrostatic interactions. The charged groups of the ligand at low ionic strength perform the ion-exchange adsorption of target protein, as the ionic strength increases the aromatic ring of the ligand allows the hydrophobic interaction to target for salt-tolerant adsorption.

As a result, high binding capacities can usually be achieved at the moderate conductivities (10-30 mS/cm) without additional dilution steps in advance. The desorption of mixed-mode adsorbent can be achieved due to the electrostatic charge repulsion, and is often accomplished by changing the pH of the mobile phase.

In general, this novel technique is especially appropriate for primary capture of target protein from moderate ionic strength feedstock without the need of dilution or other additives, which certainly improves the process efficiency and reduces the cost of primary recovery in the downstream process.

The key point is to design rationally the molecular structure of mixed-mode ligands. Currently, Prof. Lin is developing novel mixed-mode ligands for effective antibody purification, which combines the high adsorption capacity of hydrophobic groups, high selectivity of thiophilic groups and the efficient elution due to electrostatic repulsion. Several kinds of potential mixed-mode ligands have been found in the lab and coupled onto the cellulose-based adsorbents, which showed good properties for selective adsorption of antibodies.

In addition, computer-aided molecular simulation methods are used to better understand the interactions between antibody and mixed-mode ligand, while subsequently optimizing the functional groups of mixed-mode ligands for enhancing the separation efficiency of antibody purification.

The results strongly indicate that mixed-mode adsorption is a potential effective-and-economic substitute for expensive Protein-A affinity separation for antibody production. In a recent visit to Jacobs University, Prof. Lin has started to utilize computational tools (docking studies) to simulate and obtain quantitative information on mixed-mode ligand interaction with model proteins. These studies can be continued in the near future.

For further Information visit: China Bio Exchange Website

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2010-03-19T22:38:00.000+05:30

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2010-03-19T16:54:00.000+05:30

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Research Interest

2010-03-19T01:10:00.000+05:30

Bioprocess intensification and Process proteomics

Downstream processing of natural compounds

Meta-Integration in downstream processing

Aqueous two-phase extraction (e.g., reactive extraction)
Membrane adsorbents (e.g., material chemistry, ligand design)
Expanded bed adsorption (e.g., biomass effects, affinity capture, novel particles)

Continuous processing unit operations for biotechnology

Process modeling, simulation, design and scale-up

CV

2010-03-19T01:07:00.000+05:30

University Education:

Diploma in Biochemistry, University of Buenos Aires (1986)
Diploma in Industrial Pharmacy and Biochemistry, University of Buenos Aires (1993)
PhD in Industrial Microbiology and Biotechnology, University of Buenos Aires (1995)

Fellowships and Awards:

Prize "School of Pharmacy and Biochemistry", University of Buenos Aires (1996)
"Rene Hugo Thalmann" Fellowship, University of Buenos Aires (1996)
Postdoctoral Fellowship, National Research Council (Argentina) (1997-1999)
Member of the program "Return of Talents" (CIM/ZAV - BMZ) (2000-2002)

Research and Teaching Positions:

Postdoctoral Scientist, University of Düsseldorf in the Research Centre Jülich (1997-2000)
Member of the National Research Council for Science and Technology (Argentina) (since 2000)
Associate Professor for Biochemical Engineering (Downstream Processing), Jacobs University, Bremen (since 2003)

Contact

2010-03-19T00:50:00.000+05:30

Mailing address:

PO Box 750 561

28725 Bremen

Germany

Telephone: +49 421 200 3239

Fax: +49 421 200 3229

E-Mail: m.fernandez-lahore@jacobs-university.de

How to find the Jacobs University campus:

Jacobs University is in Grohn, a suburb of Bremen.

How to find us on campus:

We are in the Research III building, Room 88.